کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2166578 | 1091867 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional consequences of activating store-operated CRAC channels
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Store-operated CRAC channels, which are activated by the emptying of the endoplasmic reticulum Ca2+ stores, are an important and widespread route for triggering rises in cytoplasmic Ca2+. The cellular responses that are activated in response to Ca2+ entry through CRAC channels are being dissected out, and recent evidence has established that CRAC channels can induce both short-term (safeguarding the Ca2+ content of the endoplasmic reticulum, maintenance of cytoplasmic Ca2+ oscillations, enzyme activation, secretion) and long-term (gene expression) changes in cells. CRAC channel activation is therefore capable of evoking a range of temporally distinct responses, highlighting the versatility of this ubiquitous Ca2+ entry pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 42, Issue 2, August 2007, Pages 111-121
Journal: Cell Calcium - Volume 42, Issue 2, August 2007, Pages 111-121
نویسندگان
Anant B. Parekh,