کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2166814 1091889 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spatially organised mitochondrial calcium uptake through a novel pathway in chick neurones
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Spatially organised mitochondrial calcium uptake through a novel pathway in chick neurones
چکیده انگلیسی

A brief depolarisation of chick sensory neurones evokes a calcium increase in mitochondria that peaks 1–2 s after the depolarisation event and then decays over tens of seconds. Peripheral mitochondria take up more calcium than do central ones, even when the cytosolic calcium increase is spatially homogeneous. The calcium influx into mitochondria does not occur by the Ruthenium Red-sensitive mitochondrial calcium uniporter, and persists when the mitochondrial membrane voltage is dissipated by protonophore. These results indicate that a novel pathway, distinct from the more familiar mitochondrial calcium uniporter, allows brief electrical activity to effect significant increases of mitochondrial calcium that will in turn modulate mitochondrial energy production.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 39, Issue 3, March 2006, Pages 217–225
نویسندگان
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