کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167139 1092310 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular acidosis modulates the endocytosis and maturation of macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Extracellular acidosis modulates the endocytosis and maturation of macrophages
چکیده انگلیسی

Extracellular acidosis is involved in various pathological situations of central nervous system and the effects are largely mediated by acid sensing ion channels (ASICs). However, it remains unclear whether extracellular acidosis affects immune cells. Macrophages are immune cells that play important role in immune reactions. In this study we investigated the impact of extracellular acidosis on the function of bone marrow derived macrophages (BMMs). The results showed that extracellular acidosis upregulated the endocytosis, surface molecular expression and interleukin-10 secretion of BMMs, in which the expression of ASIC1 and ASIC3 was detected. Notably, extracellular acidosis stimulated endocytosis and upregulation of surface molecules expression in BMMs could be abolished by amiloride, a blocker of ASICs, and nonsteroid anti-inflammatory drugs. Our findings provide new insight into the role of extracellular acidosis in the regulation of immune function and suggest ASICs as new targets for the modulation of immune response.


► Extracellular acidosis affects the funtion of macrophages.
► Bone marrow derived macrophages express acid sensing ion channels.
► Upregulation of surface molecules in BMMs could be abolished by amiloride.
► Upregulation of surface molecules in BMMs could be abolished by NSAIDs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 281, Issue 1, January 2013, Pages 44–50
نویسندگان
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