کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167141 | 1092310 | 2013 | 6 صفحه PDF | دانلود رایگان |
Prostaglandin E2 has been shown to enhance the maturation, migration, and antigen-presenting capacity of DCs. It is therefore included in many maturation cocktails for the generation of monocyte-derived DCs. Paradoxically, PGE2 is also an important tumor-derived immunosuppressive factor and has inhibitory effects on DC differentiation and function. To further investigate these seemingly contradictory results we studied whether the DC:T cell ratio has an impact on the outcome of the interaction between PGE2-treated DCs and T cells. Surprisingly, at high DC:T cell ratios T cell proliferation was inhibited while at low ratios PGE2-treated DCs displayed enhanced T cell-stimulatory properties. The inhibitory function of PGE2-treated DCs depended primarily on the PGE2-induced induction of indoleamine 2,3-dioxygenase competence. In summary, we show that PGE2-treated DCs can have either an immunogenic or tolerogenic function depending on the DC:T cell ratio. This finding could explain the conflicting results regarding the influence of PGE2 on DC function.
► Depending on the DC:T cell ratio PGE2-treated DCs have opposite effects on T cells.
► At high ratios DCs are immunostimmulatory while at low ratios they are tolerogenic.
► The tolerogenic effect of PGE2-treated DCs depends on the induction of IDO.
► Inhibition of IDO inhibits the tolerogenic effects of PGE2 at high DC:T cell ratios.
Journal: Cellular Immunology - Volume 281, Issue 1, January 2013, Pages 62–67