The spider acylpolyamine Mygalin is a potent modulator of innate immune responses

► Mygalin is a synthetic bis-acylpolyamine from spider Acanthoscurria gomesiana with antimicrobial activity. ► Mygalin is a modulator of innate immune responses. ► Mygalin increased the IFN-γ, nitric oxide and TNF-α secretion. ► Mygalin can be exploited for increase the control of infection.