کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167613 1092343 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes
چکیده انگلیسی

The major γδ T cell subset in the human peripheral blood expresses the Vγ9δ2 TCR and recognizes non-peptidic prenyl pyrophosphate antigens such as isopentylpyrophosphate (IPP). Upon activation the γδ T cells rapidly secrete antiviral cytokines similar to classical memory αβ T cells. Here we have investigated the ability of γδ T lymphocytes from human PBMC to become activated by influenza A virus infection. Vγ9Vδ2 T lymphocytes rapidly upregulate expression of CD25 and CD69 and produce IFN-γ following influenza infection of PBMC. Moreover, the recognition is cross-reactive between various subtypes of influenza, but not with vaccinia virus. Vγ9Vδ2 T cell responses are potently reduced by the HMG-CoA reductase inhibitor mevastatin, which inhibits the mevalonate pathway and IPP synthesis. Our results indicate that influenza virus infection induces the rapid activation and function of Vγ9Vδ2 T lymphocytes in the peripheral blood via a mechanism that depends on the mevalonate pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 264, Issue 1, 2010, Pages 71–77
نویسندگان
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