Keywords: Mevalonate; Mevalonolactone; Fermentation; Chiral;
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Keywords: Farnesol; Isoprenoid biosynthesis; Methylerythritol phosphate; Mevalonate; Plants; Protein prenylation; DX; 1-deoxy-d-xylulose; FOS; fosmidomycin; FPP; farnesyl diphosphate; GGPP; geranylgeranyl diphosphate; HMGR; 3-hydroxy-3-methylglutaryl coenzyme A red
Keywords: Mevalonate; p53; Malignancy; Immune surveillance;
Keywords: IspS; isoprene synthase; DMAPP; dimethylallyl pyrophosphate; MEP; methylerythritol phosphate; MEV; mevalonate; IPTG; isopropyl β-D-1-thiogalactopyranoside; CDW; cell dry weight; TSP; terpene synthase; TSP-b; terpene synthase protein family clade b; MSA;
Keywords: MEP; methylerythritol phosphate; MVA; mevalonate; DXS; deoxyxylulose-5-phosphate synthase; HMGR; hydroxymethylglutaryl coenzyme A reductase; DOX; 1-deoxy-d-xylulose; IPP; isopentenyl diphosphate; DMAPP; dimethylallyl diphosphate; Gossypium hirsutum L. (co
Keywords: Mevalonate; Statins; Bisphosphonates; Prenylation; Caspase-1; Innate immunity;
Keywords: FT; farnesyltransferase; SHR; spontaneously hypertensive rat; WKY; Wistar-Kyoto rat; FTI; farnesyltransferase inhibitor; ERK1/2; extracellular-signal regulated kinases 1/2; FPP; farnesyl pyrophosphate; MVA; mevalonate; TGF-β1; transforming growth factor-
Keywords: Mevalonate; 6-Fluoromevalonate; 6,6,6-Trifluoromevalonate; Prodrugs; Plasma stabilityDMP, diphosphomevalonate; MK, mevalonate kinase; PMK, phosphomevalonate kinase; DPM, 6-fluoro- and 6,6,6-trifluoro-5-diphosphomevalonate; DPM-DC, diphosphomevalonate deca
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production
Keywords: Norcardia terpenica IFM0406; Mevalonate pathway; Isoprenoids; Prenyltransferases; Aact; acetoacetyl CoA thiolase; BraA; brasilicardin A; BraB; brasilicardin B; BraC; brasilicardin C; BraD; brasilicardin D; BraC-agl; brasilicardin C aglycon; BraD-agl; bras
In-situ isopentenol production from Bacillus subtilis through genetic and culture condition modulation
Keywords: CSIR; Council for Scientific and Industrial Research; DMAPP; Dimethylallyl pyrophosphate; DXP; 1-deoxy-d-xylulose-5-phosphate; dxs; 1-deoxy-d-xylulose-5-phosphate synthase; G3P; Glyceraldehyle-3-phosphate; GC-FID; Gas Chromatography-Flame Ionization Det
Endophytic Pseudomonas induces metabolic flux changes that enhance medicinal sesquiterpenoid accumulation in Atractylodes lancea
Keywords: Atractylodes lancea; Bacterial endophyte; Conversion; Metabolic flux change; Medicinal terpenoid; Microbial elicitor; ABA; abscisic acid; acetyl CoA; acetyl coenzyme A; ANOVA; a one-way analysis of variance; ET; ethylene; GA; gibberellin; GC; gas chroma
Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng
Keywords: ANOVA; analysis of variance; Ct; cycle threshold value; CYP450; cytochrome P450; DS; dammarenediol synthase gene; DS; dammarenediol synthase; FPS; farnesyl pyrophosphate synthase gene; FPS; farnesyl pyrophosphate synthase; GAPDH; glyceraldehyde phosphate
Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells
Keywords: Dexamethasone (PubChem CID: 5743), simvastatin (PubChem CID: 54454); Y27632 (PubChem CID: 448042); Oxidative stress; HDAC2; A549 cells; Mevalonate; Statins;
Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib
Keywords: CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh
Production of sesquiterpenoid zerumbone from metabolic engineered Saccharomyces cerevisiae
Keywords: CPR; cytochrome P450 reductase; CYP71BA1; α-humulene 8-hydroxylase; GLC; Glucose; Humulene; α-humulene; MVA; mevalonate; OHum; 8-hydroxy-α-humulene; ZSS1; α-humulene synthase; ZSD1S114A; zerumbone synthase variant (S144A); α-humulene; 8-hydroxy-α-hu
Nerolidol production in agroinfiltrated tobacco: Impact of protein stability and membrane targeting of strawberry (Fragraria ananassa) NEROLIDOL SYNTHASE1
Keywords: FDP; farnesyl diphosphate; GCMS; gas chromatography-mass spectrometry; SPME; solid phrase microextraction; IDP; isopentenyl diphosphate; DMADP; dimethylallyl diphosphate; MEP; 2-C-methyl-d-erythritol 4-phosphate; MVA; mevalonate; DMNT; 4,8-dimethyl-1,3,
Over-expression of 3-hydroxy-3- methylglutaryl-coenzyme A reductase 1 (hmgr1) gene under super-promoter for enhanced latex biosynthesis in rubber tree (Hevea brasiliensis Muell. Arg.)
Keywords: Genetic transformation; Hevea brasiliensis; Latex biosynthesis; Over expression; Rubber tree; Tapping panel dryness; Transgenic plant; ABA; Abscisic acid; BA; 6 benzylaminopurine; 2, 4 - D; 2, 4-Dichloro phenoxyacetic acid; GA3; Gibberellic acid; HMGR1; 3
Metabolic engineering of mevalonate-producing Escherichia coli strains based on thermodynamic analysis
Keywords: 2PG; 2-phosphoglycerate; 3PG; 3-phosphoglycerate; 6PG; 6-phosphogluconate; 6PGDH; 6-phosphogluconate dehydrogenase; 6PGL; 6-phosphogluconolactonase; AcCoA; acetyl coenzyme A; ACO; cis-aconitate; AKG; α-ketoglutarate; CIT; citrate; CoA; coenzyme A; DHAP;
13C-metabolic flux analysis for mevalonate-producing strain of Escherichia coli
Keywords: 13C-metabolic flux analysis; Mevalonate; Escherichia coli; [1-13C] glucose; Flux distribution; Redox balance; Flux balance analysis;
Metabolic impact of nutrient starvation in mevalonate-producing Escherichia coli
Keywords: Mevalonate; Escherichia coli; Nutrient starvation; 13C-metabolic flux analysis;
Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1
Keywords: FOH; farnesol; GGOH; geranylgeraniol; HMG-CoA; 3-hydroxy-3-methyl-3-glutaryl coenzyme A; MVA; mevalonate; LDL-C; low-density lipoprotein cholesterol; LPDS; lipoprotein plasma-deprived serum; PCSK9; proprotein convertase subtilisin/kexin type 9; SOCS3; sup
High titer mevalonate fermentation and its feeding as a building block for isoprenoids (isoprene and sabinene) production in engineered Escherichia coli
Keywords: Mevalonate; Isoprene; Sabinene; Betaine; Biosynthesis;
Original Research ArticleBiosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply
Keywords: Methylobacterium extorquens AM1; QscR regulation; Biosensor; Cyclic pathway; Acetyl-CoA; Mevalonate;
Manual and expert annotation of the nearly complete genome sequence of Staphylococcus sciuri strain ATCC 29059: A reference for the oxidase-positive staphylococci that supports the atypical phenotypic features of the species group
Keywords: Oxidase-positive Staphylococcus; Phosphoenolpyruvate:carbohydrate phosphotransferase systems; ATP-binding cassette systems; Two-component regulatory systems; Mevalonate; Iron transport;
Peroxisome proliferator-activated receptor γ down-regulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes
Keywords: Tocotrienol; Lovastatin; Adipocyte; Mevalonate; PPARγ; ANOVA; analysis of variance; C/EBPα; CCAAT/enhancer-binding protein α; FAS; fatty acid synthase; GLUT4; glucose transport protein 4; HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A; PBS; phosphate-b
Biosynthesis of β-caryophyllene, a novel terpene-based high-density biofuel precursor, using engineered Escherichia coli
Keywords: β-Caryophyllene; DXP pathway; MVA pathway; Escherichia coli; DMAPP; dimethylallyl pyrophosphate; IPP; isopentenyl pyrophosphate; GPP; geranyl diphosphate; MVA; mevalonate; DXP; 1-Deoxy-d-Xylulose 5-Phosphate; IPTG; isopropyl β-D-thiogalactoside; PCR; po
Functional and conformational transitions of mevalonate diphosphate decarboxylase from Bacopa monniera
Keywords: Mevalonate diphosphate decarboxylase; Unfolding; Aggregation; Fluorescence quenching; CD spectroscopy; BmMDD; Bacopa monniera mevalonate diphosphate decarboxylase; CD; circular dichroism; GdnHCl; Guanidine hydrochloride; MEP; 2-C methyl-d-erythritol-4-pho
CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production
Keywords: CRISPR; Clustered regularly interspaced short palindromic repeats; CRISPRi; Clustered regularly interspaced short palindromic repeats interference; MVA; mevalonate; sgRNA; single guide RNA; dCas9; inactive Cas9; IPP; isopentenyl diphosphate; DMAPP; dimeth
Two different subcellular-localized Acetoacetyl-CoA acetyltransferases differentiate diverse functions in Magnaporthe oryzae
Keywords: Acetoacetyl-CoA acetyltransferase; Mevalonate; Morphogenesis and pathogenesis; Magnaporthe oryzae
Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae
Keywords: CRISPR; clustered regularly interspaced short palindromic repeat; PAM; protospacer adjacent motif; BTS1; Geranylgeranyl pyrophosphate synthase; ROX1; Heme-dependent repressor of hypoxic genes; TALEN; transcription activator-like effector nuclease; gRNA; g
Disruption of the mevalonate pathway induces dNTP depletion and DNA damage
Keywords: ACN; acetonitrile; BrdU; 5-bromo-2â²-deoxyuridine; DMAPP; dimethylallyl diphosphate; dNs; deoxyribonucleosides; dNTP; deoxyribonucleoside triphosphate; E2F; E2 transcription factor; Fmev; 6-fluoromevalonate; IPP; isopentenyl diphosphate; HU; hydroxyurea;
Inhibitory effects of pitavastatin on fibrogenic mediator production by human lung fibroblasts
Keywords: Pulmonary fibrosis; Statin; Mevalonate; Transforming growth factor-β;
Cloning and expression analysis of ten genes associated with picrosides biosynthesis in Picrorhiza kurrooa
Keywords: MVA; mevalonate; MEP; 2-C-methyl-d-erythritol 4-phosphate; DXS; 1-deoxy-d-xylulose-5-phosphate synthase; DXR; 1-deoxy-d-xylulose-5-phosphate reductoisomerase; MCT; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; CMK; 4-diphosphocytidyl-2-C-methy
Uniconazole, a cytochrome P450 inhibitor, inhibits trans-zeatin biosynthesis in Arabidopsis
Keywords: ABA; abscisic acid; BA; 6-benzylaminopurine; BR; brassinosteroid; βGlc; β-glucosidase; CK; cytokinin; CKXs; cytokinin oxidase/dehydrogenases; cZ; cis-zeatin; cZR; cis-zeatin riboside; cZRMP; cis-zeatin riboside 5â²-monophosphate; cZRPs; cis-zeatin ribo
Pathophysiology of BRONJ: Drug-related osteoclastic disease of the jaw
Keywords: Osteonecrosis; Bisphosphonate; Osteoclast; Mevalonate
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
Keywords: statins; isoprenoids; protein prenylation; synaptic plasticity; hippocampus; long-term potentiation; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; Akt; protein kinase B; fEPSPs; field excitatory postsynaptic potentials; FPP; farnesyl py
The single cellular green microalga Botryococcus braunii, race B possesses three distinct 1-deoxy-d-xylulose 5-phosphate synthases
Keywords: MEP; methylerythritol 4-phosphate; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; IPP; isopentenyl diphosphate; DMAPP; dimethylally diphosphate; MVA; mevalonate; DXP; 1-deoxy-d-xylulose 5-phosphate; NTR; non-translated region; TLC; thin-layer chromatograph
Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae
Keywords: Algae; Isoprenoid; Terpenoid; Methylerythritol phosphate; Mevalonate; Prenyltransferase
Polyisoprenoids - Secondary metabolites or physiologically important superlipids?
Keywords: IPP; isopentenyl diphosphate; MVA; mevalonate; MEP; methylerythriol phosphate; CPT; cis-prenyltransferase; AtCPT; Arabidopsiscis-prenyltransferase; UPPS; undecaprenyl diphosphate synthase; DHDDS; dehydrodolichyl diphosphate synthase; RT-PCR; reverse trans
Microbial production of isoprenoids
Keywords: IPP; isopentenyl pyrophosphate; MEP; methylerythritol phosphate; DMAPP; dimethylallyl diphosphate; GPP; geranyl diphosphate; FPP; farnesyl diphosphate; MevT; Mevalonate “top” operon; MBIS; Mevalonate “bottom” operon; HMGS; HMG-CoA synthase; tHMGR;
ReviewBiochemical and molecular mechanisms of action of bisphosphonates
Keywords: Prenylation; GTPase; Mevalonate; FPP; GGPP; IPP; ApppI; Cholesterol;
The thermoacidophilic archaeon Sulfolobus acidocaldarius contains an unsually short, highly reduced dolichyl phosphate
Keywords: Acetate; Ac; Chloroform; CHCl3; cis-polyprenyl diphosphate synthase; CPDS; Collision-induced dissociation; CID; Deoxyxylulose phosphate; DOXP; Dimethylallyl diphosphate; DMAPP; Dolichyl phosphate; DolP; Geranylgeranyl diphosphate; GGPP; Geranylgeranyl red
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes
Keywords: Gamma delta; T cell; Mevalonate; Influenza; Activation; TCR; Peripheral blood; IFN-γ; Infection; PBMC
Atorvastatin affects TLR4 clustering via lipid raft modulation
Keywords: Atherosclerosis; Statins; Toll-like receptor 4; Lipid raft; Mevalonate
Simvastatin attenuates acrolein-induced mucin production in rats: Involvement of the Ras/extracellular signal-regulated kinase pathway
Keywords: Muc5ac; Acrolein; Simvastatin; Mevalonate; Ras
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study
Keywords: Terpene; Biosynthesis; Mevalonate; 1-Deoxyxylulose phosphate; Artemisinin;
Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways
Keywords: Arabidopsis thaliana; Regulation of plant metabolism; Isoprenoids; Mevalonate; Myriocin; Sphingolipids; 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR);
Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life
Keywords: LLO; lipid-linked oligosaccharide; OST; oligosaccharide transferase; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; MVA; mevalonate; DOXP; 1-deoxy-D-xylulose-5-phosphate; HMG-CoA; 3-hydroxy-3methylglutaryl-CoA; HMGS; HMG-CoA synthase;
Leishmania amazonensis: Biosynthesis of polyprenols of 9 isoprene units by amastigotes
Keywords: Leishmania; Amastigotes; Polyisoprenoids; Dolichol; Mevalonate; HPTLC, high performance thin layer chromatography; RP-HPLC, reversed-phase high performance liquid chromatography; FBS, foetal bovine serum; Pren-n, polyprenol of n isoprene units; Dol-n, dol