کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371482 1302524 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leishmania amazonensis: Biosynthesis of polyprenols of 9 isoprene units by amastigotes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Leishmania amazonensis: Biosynthesis of polyprenols of 9 isoprene units by amastigotes
چکیده انگلیسی

The isoprenoid metabolic pathway in protozoa of the Leishmania genus exhibits distinctive characteristics. These parasites, as well as other members of the Trypanosomatidae family, synthesize ergosterol, instead of cholesterol, as the main membrane sterol lipid. Leishmania has been shown to utilize leucine, instead of acetate as the main precursor for sterol biosynthesis. While mammalian dolichols are molecules containing 15–23 isoprene units, Leishmania amazonensis promastigotes synthesize dolichol of 11 and 12 units. In this paper, we show that the intracellular stages of L. amazonensis, amastigotes, synthesize mainly polyprenols of 9 isoprene units, instead of dolichol.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 118, Issue 4, April 2008, Pages 624–628
نویسندگان
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