کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167977 1092365 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells
چکیده انگلیسی

Supernatant obtained from high dose hydrocortisone resistant thymocytes can induce migration of the bone marrow cell precursors to the periphery. This biological activity depends on the presence of the 18 kDa protein, whose amino acid sequence fits with the sequence of the secretory form of murine cyclophilin A (SP-18). Cyclophilin A isolated from the supernatant of the cortisone-resistant thymoma EL-4 shows its characteristic functional features as it demonstrates isomerase activity and binds with cyclosporine A. The cyclophilin A obtained manifests chemotactic activity that regulates migration of bone marrow cell precursors of neutrophils, T-, B- and dendritic cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 249, Issue 1, September 2007, Pages 46–53
نویسندگان
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