کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2168102 1092375 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human intestinal αβ IEL clones in celiac disease show reduced IL-10 synthesis and enhanced IL-2 production
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Human intestinal αβ IEL clones in celiac disease show reduced IL-10 synthesis and enhanced IL-2 production
چکیده انگلیسی

Celiac disease is a gluten-induced T-cell mediated autoimmune process that results in the destruction of the intestinal mucosa and is associated with an expansion of CD8+ CD103+ TCRαβ intraepithelial lymphocytes (IELs) in the damaged epithelium. The role of this IEL population in the pathology is unknown. The aim of this work was to compare the cytokine profile and the cytotoxicity pattern from CD8+ IEL clones isolated from celiac (CD) and non-celiac (NCD) biopsies. We report that the number of IL-10 producing CD clones was significantly lower (26%) than that obtained from the NCD sample (62%). Instead, IL-2 was produced by more CD (44%) than NCD clones (26%). Cytotoxicity patterns against intestinal epithelial cell lines suggest different functional subsets of CD8+ IELs. CD clones capable of high cytotoxicity produced IL-2 whereas most cytotoxic NCD IELs produced IL-10. This clonal analysis indicates that an impaired immune regulation in celiac mucosa may be partially attributed to the low generation of regulatory CD8+ IELs that produce IL-10.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 244, Issue 1, November 2006, Pages 1–9
نویسندگان
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