کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2168172 1092380 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells
چکیده انگلیسی

We have previously determined the protective efficacy of intranasal vaccination with chlamydial protease-like activity factor (CPAF) against genital chlamydial infection. Since T-helper 1 (Th1) responses are important for anti-chlamydial immunity, we examined the contribution of CD4+ T cells in CPAF mediated immunity against intravaginal (i.vag.) Chlamydia muridarum infection in C57BL/6 mice. CPAF+IL-12 vaccination induced antigen-specific CD4+ T cells that secreted elevated levels of IFN-γ, and generated strong humoral responses. The protective effects of CPAF vaccination against genital chlamydial challenge were abrogated by anti-CD4 neutralizing antibody treatment. Moreover, anti-chlamydial immunity could be adoptively transferred to naïve recipients using CPAF-specific CD4+ T cells. Therefore, CPAF mediated anti-chlamydial immunity is highly dependent upon antigen-specific CD4+ T cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 242, Issue 2, August 2006, Pages 110–117
نویسندگان
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