کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170495 | 1093381 | 2015 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use](/preview/png/2170495.png)
The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the innate immunity. As current schedules of treatment for chronic hepatitis C and for hematological and solid tumors, based on the continuous administration of recombinant type I IFN or pegylated formulations, disregard viral resistance, host genetic variants predicting treatment outcome and mechanisms of refractoriness, new administration schedules, the combination of type I IFN with new drugs and the increased monitoring of patients’ susceptibility to type I IFN are expected to provide a new life to this valuable cytokine.
Journal: Cytokine & Growth Factor Reviews - Volume 26, Issue 2, April 2015, Pages 121–131