کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170543 1093385 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers
چکیده انگلیسی

Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors signal through intertwining signaling cascades which result in the expression of pro-inflammatory cytokines and type I interferons. Conjugation, or binding, of ubiquitin and ubiquitin-like modifiers (UBLs) to a plethora of immune signaling molecules forms a common theme in innate immune regulation. Numerous E3 ligases and deubiquitylating enzymes (DUBs) actively modify signaling components in order to achieve a balanced activation of the innate immune system. This review will discuss how this balance is achieved and which questions remain regarding innate immune regulation by ubiquitin and UBLs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 23, Issue 6, December 2012, Pages 273–282
نویسندگان
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