Keywords: Mitochondria; Ubiquitin; Neurodegeneration; E3 ligase; Mitochondria-derived vesicles; PD; Parkinson's disease; MDV; mitochondria-derived vesicle; DA; dopaminergic; SN; substantia nigra; GWAS; genome-wide association study; OMM; outer mitochondrial membran
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Keywords: PEDV; Papain-like protease; 6-Thioguanine; Noncompetitive inhibition; Alpha coronavirus; AUC; The abbreviations used are analytical ultracentrifugation; CoV; coronavirus; DUB; deubiquitinating; MERS; Middle East respiratory syndrome; βME; β-mercaptoetha
Keywords: PTM; post-translational modification; RBR; RING-between-RING; DUB; deubiquitinase; USP; ubiquitin-specific protease; SCF; Skp1-Cullin-F-box; CaMKII; Ca2Â +/calmodulin-dependent kinase 2; Cbl; Casitas B-lineage lymphoma; TKB; tyrosine kinase binding; RTK;
Keywords: PINK1; Parkin; Autophagy; Mitophagy; Parkinson's Disease; Drosophila; DUB;
Keywords: APAP; acetaminophen; ALD; alcoholic liver disease; BAG4; Bcl2-associated athanogene 4; CCCP; carbonyl-cyanide m-chlorophenyl hydrazine; Clec16a; c-type lectin domain family 16, member A; Dfcp1; double FYVE-containing protein 1; DUB; deubiquitinating enzym
Keywords: AD; Alzheimer's disease; ADCA; autosomal dominant cerebellar ataxia; AMPA receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; Atx2mut; mutant ataxin-2; Aβ peptides; amyloid beta peptides; BACE1; beta
Keywords: AFC; 7-amino-4-trifluoro-methylcoumarin; CoV; coronavirus; DUB; deubiquitination; MERS; Middle East respiratory syndrome; 6MP; 6-mercaptopurine; NEM; N-ethylmaleimide; PLpro; papain-like protease; SARS; severe acute respiratory syndrome; 6TG; 6-thioguanin
Keywords: Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; DUB; α,βâUnsaturated ketones; Apoptosis;
Keywords: AJ; adherens junction; APC; adenomatous polyposis coli; ARD; armadillo repeat domain; ARVC; arrhythmogenic right ventricular cardiomyopathy; Bsk; Basket; CaM; calmodulin; Cav-1; caveolin-1; CCM; cerebral cavernous malformations; Ccm3; cerebral cavernous m
Keywords: Hb-Y-X; hydrophobic-tyrosine-X motif; PA; proteasome activator; CSN; COP9 signalosome; CRL; Cullin RING E3 ligase; PAN; proteasome-activating nucleotidase; Ribophagy; Ribosome autophagy; UbD; ubiquitin-binding domain; DUb; deubiquitinationg enzyme; UPS; u
Keywords: A; androsterone; amu; atomic units; CIR; carbon isotopic ratio; C.V.%; coefficient of variance; DUB; dysfunctional uterine bleeding; E1; estrone; E2; 17β-estradiol; E3; estriol; Etio; etiocholanolone; eV; electron volt; GC-C-IRMS; gas chromatography
Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
Keywords: USP; ubiquitin specific peptidase; DUB; deubiquitinase; biotin-UbVME; biotin-ubiquitin-vinylmethyl ester; BrdU; bromodeoxyuridine; Mitophagy; Deubiquitinase inhibitor; Parkin; USP30;
USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2
Keywords: EMT; Deubiquitinase; DUB; Cancer; Slug; USP10;
Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Keywords: 20S; core 20S proteasome; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BBB; blood-brain barrier; DUB; deubiquitinating enzyme; HbYX; hydrophobic-tyrosine-unspecified residue 'X'; IDP; intrinsically disorder
LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells
Keywords: HBO1; histone acetyltransferase binding to origin recognition complex 1; UPS25; ubiquitin specific peptidase 25; LPS; lipopolysaccharide; Cdt1; Chromatin Licensing And DNA Replication Factor 1; HDAC11; histone deacetylase 11; MCM; Minichromosome Maintenan
Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth
Keywords: PDA; pancreatic ductal adenocarcinomas; PanIN; pancreatic epithelial lesions; GFR; growth factor reduced; DOX; doxycycline; 3D; three-dimensional; Usp9x-OV; Usp9x overexpression; DUB; deubiquitinase;
Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: Insight from cadmium
Keywords: CI; CII, CIII, CIV, CV, complexes I, II, III, IV, V of mitochondrial respiratory chain; TTFA; thenoyltrifluoroacetone; RLM; rat liver mitochondria; ROS; reactive oxygen species; dUb; decylubiquinone; mtETC; mitochondrial electron transport chain; MPT; mit
ESCRT-dependent cargo sorting at multivesicular endosomes
Keywords: DUB; deubiquitinating enzyme; DUIM; double ubiquitin-interacting motif; EGF; epidermal growth factor; ESCRT; endosomal sorting complex required for transport; GLUE; GRAM-like ubiquitin-binding in Eap45; ILV; intralumenal vesicle; LBPA; lysobisphosphatidic
Alzheimer's disease-associated ubiquitin mutant Ubb+1: Properties of the carboxy-terminal domain and its influence on biomolecular interactions
Keywords: AD; Alzheimer's disease; CSP; chemical shift perturbation; DUB; deubiquitinating enzyme; hetNOE; heteronuclear nuclear Overhauser effects; HSQC; heteronuclear single quantum coherence; POPC; palmitoyl oleoyl phosphatidylcholine; POPG; palmitoyl oleoyl p
Ubiquitin protease Ubp8 is necessary for S. cerevisiae respiration
Keywords: HAT; histone-acetyltransferase; Gcn5; General Control Nonderepressible; HDAC; histone deacetylase; CPTH2; cyclopentylidene-[4-(4â²-chlorophenyl)thiazol-2-yl)hydrazone; Ubp8; ubiquitin protease 8; DUB; deubiquitylation; Psh1; E3-ubiquitin ligase; Ub; ubiq
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
Keywords: MERS- and SARS-CoV; Papain-like protease; Disulfiram; 6-Thioguanine; Mycophenolic acid; Synergistic inhibition; CoV; coronavirus; Mpro; main protease; DDC; diethyldithiolcarbamate; DUB; deubiquitination; MERS; Middle East respiratory syndrome; βME; β-me
Polyglutamine expansion diseases: More than simple repeats
Keywords: Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
Keywords: Ubiquitin-like domain; Papain-like protease; Macrodomain; Nucleic-acid binding domain; Innate immunity; Structural biology; 3CLpro; 3C-like protease; 3Ecto; Nsp3 ectodomain; ADPr; ADP-ribose; ADRP; ADP-ribose-1â³-phosphate phosphatase; ARTD; ADP-ribosylt
The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2
Keywords: DUB; Male infertility; Mdm2; Spermatozoa; USP26;
Reviewp53 stability is regulated by diverse deubiquitinating enzymes
Keywords: UPP; Ubiquitin-proteasome pathway; DUB; Deubiquitinating enzyme; PTM; Post-translational modification; E1; Ubiquitin-activating enzyme; E2; Ubiquitin-conjugatng enzyme; E3; Ubiquitin ligase; RING; Really interesting new gene; HECT; Homologous to E6-AP car
Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53
Keywords: Mdm2; mouse double minute 2 homolog; RING; really interesting new gene; DUB; deubiquitinase; USP; ubiquitin-specific protease; OTU; ovarian tumor proteases; OTUD1; ovarian tumor domain-containing protein 1; UIM; ubiquitin interacting motif; PI; propidium
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites
Keywords: Ataxin-3; Spinocerebellar ataxia type 3; Mass spectrometry; Neurodegeneration; Ubiquitination; Phosphorylation; DUB; deubiquitinating enzyme;; HD; Huntington's disease; HEK; human embryonic kidney;; LC-MS/MS; liquid chromatography tandem mass spectrometry
Traveling Rocky Roads: The Consequences of Transcription-Blocking DNA Lesions on RNA Polymerase II
Keywords: RNAP2; RNA polymerase II; TBL; transcription-blocking lesion; TCR; transcription-coupled DNA repair; TFIIS; transcription factor IIS; CS; Cockayne syndrome; CSB; Cockayne syndrome B; DUB; de-ubiquitylating enzyme; pVHL; von Hippel-Lindau tumor suppresso
Histone ubiquitination in the DNA damage response
Keywords: DSB; DNA double strand breaks; HR; homologous recombination; NHEJ; non homologous end-joining; PTM; post-translational modification; DUB; deubiquitinating enzyme; USP; ubiquitin specific protease; PRC; polycomb repressive complex; RING; really interesting
Immune defects caused by mutations in the ubiquitin system
Keywords: Ubiquitin; nuclear factor κB; immunodeficiency; CVID; Common variable immunodeficiency; DUB; Deubiquitinating enzyme; EDA-ID; Ectodermal dysplasia with immunodeficiency; HECT; Homologous to EGAP C-terminus; HOIL-1; Heme-oxidase iron responsive element bi
The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance
Keywords: BMP; bone morphogenetic protein; CSC; cancer stem cell; DUB; deubiquitinase; EIF; EMT-inducing transcriptional factor; EMT; epithelial-mesenchymal transition; GSC; glioma stem cell; HIF; hypoxia inducible factor; IAP; inhibitors of apoptosis; ID; inhibito
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes
Keywords: Proteostasis; Ubiquitination; Deubiquitination; Neurodegeneration; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; Nrf1; NF-E2-related factor 1; NFE2L1; NF-E2-like 1; qRT-PCR; quantitative real time- PC
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear
Keywords: DUB; Deubiquitinase; ERAD; endoplasmic-reticulum associated degradation; ESI; electrospray ionization; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; ITC; isothermal titration calorimetry; ML; maximum-likelihood; RING; really-interesting new g
Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity
Keywords: cSENP1; catalytic human SUMO-specific protease; DUB; deubiquitinating enzyme; IC50; half maximal inhibitory concentration; rhSENP1; recombinant human SUMO-specific protease; SENP; SUMO-specific protease; SUMO; small ubiquitin-related protein modifier; SUM
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression
Keywords: Ubiquitination; Deubiquitination; Proteasomal degradation; Transcription factor; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; ER; endoplasmic reticulum; NHB1; N-terminal homology box 1; Nrf1; NF-
Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
Keywords: E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology
The missing links to link ubiquitin: Methods for the enzymatic production of polyubiquitin chains
Keywords: Ubiquitin; Post-translational modification; Ligation; Enzymatic ubiquitination; Ubiquitinating enzymes; Protein purification; Ub; ubiquitin; ATP; adenosine triphosphate; YUH1; yeast protease Ub hydrolase-1; DTT; dithiothreitol; EDTA; ethylenediaminetetraa
Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance
Keywords: Fbw7; Cancer; Ubiquitin; USP28; DUB;
Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling
Keywords: Ubiquitin; Innate immunity; TNF; TLR3; NOD1; LUBAC; AMSH-LP; AMSH-like protein; λ-PPase; bacteriophage λ protein phosphatase; BMDM; bone marrow-derived macrophages; JNK; c-Jun N-terminal kinase; cIAP; cellular Inhibitor of Apoptosis; DUB; deubiquitylase
The ubiquitin-like modifier FAT10 in cancer development
Keywords: AIPL1; aryl-hydrocarbon receptor like-1; APC/C; anaphase-promoting complex/cyclosome; DUB; deubiquitylating enzyme; EMT; epithelial-mesenchymal transition; FAT10; HLA-F adjacent transcript 10; GSK; glycogen synthase kinase; HCC; hepatocellular carcinoma;
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication
Keywords: Initiation of DNA replication; DNA damage response; Ubiquitin hydrolase; DNA damage; Protein degradation; Proteasome; DUB; deubiquitinating enzyme;
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme
Keywords: Ubiquitin Specific Protease 17; DUB3; Ubiquitin; Protein refolding; USP17; Deubiquitinating; DUB; deubiquitinating enzyme; USP; Ubiquitin Specific Protease; Ub; ubiquitin; CDC25A; cell division cycle 25A; RCE1; Ras converting enzyme 1; IPTG; isopropyl β-
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins
Keywords: GPCR; β-arrestin; KLHL12; ubiquitination; dopamine D4 receptor; β2AR; β2-adrenergic receptor; ADHD; attention deficit hyperactivity disorder; BTB; bric à brac 1, tramtrack, and broad-complex; co-IP; co-immunoprecipitation; CXCR4; C-X-C chemokine recep
The mitochondrial unselective channel in Saccharomyces cerevisiae
Keywords: ANT; adenine-nucleotide translocase; CoxIV1-22; mitochondrial targeting sequence of cytochrome oxidase subunit IV; CPR3; yeast mitochondrial cyclophilin; CsA; cyclosporine A; CypD; cyclophilin D; dUb; decylubiquinone; dVO4; decavanadate; EGTA; ethylene gl
Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma
Keywords: BAP1; BRCA1-associated protein-1; MCRS1; microspherule protein 1; ccRCC; clear cell renal cell carcinoma; DUB; de-ubiquitination enzymes; Co-IP; co-immunoprecipitation; BAP1; MCRS1; Clear cell renal cell carcinoma; Chromosome instability; De-ubiquitinatio
BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells
Keywords: ASXL1; additional sex combs-like 1; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer gene 1; CSC; cancer stem cells (CSC); DTB; double thymidine block; DUB; deubiquitinating enzyme; E2F1; E2F transcription factor 1; FOXK; the forkhead transcription
Mechanisms of p53 degradation
Keywords: ATM; ataxia telangiectasia mutated; CHIP; C-terminus of HSP70-interacting protein; CBP; CREB binding protein; COP1; constitutively photo-morphogenic 1; DDB1; DNA damage binding protein 1; DHFR; dihydrofolate reductase; DUB; de-ubiquitinating enzyme; E1; u
Phlebotomus papatasi exposure cross-protects mice against Leishmania major co-inoculated with Phlebotomus duboscqi salivary gland homogenate
Keywords: DUB; Phlebotomus duboscqi; EXP; exposed; L.; Leishmania; Lu.; Lutzomyia; NB; nitrocellulose membrane; nEXP; non-exposed; P.; Phlebotomus; p.i.; post infection; PAP; Phlebotomus papatasi; PMΦ; peritoneal macrophages; SGH; salivary gland homogenate; SI; st
Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting
Keywords: Ubiquitin; Ubiquitin-binding-domain; Immunoblotting; Deubiquitylase; Ubiquitin chain topology; DMP; dimethyl pimelidinate; DUB; deubiquitylase; GST; glutathione S-transferase; HEK; human embryonic kidney; IAA; iodoacetamide; IL-1R; IL-1 receptor; IMAC; im