کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170820 | 1549506 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autophagy and NF-κB: Fight for fate
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Autophagy/macroautophagy is known for its role in cellular homeostasis, development, cell survival, aging, immunity, cancer and neurodegeneration. However, until recently, the mechanisms by which autophagy contributes to these important processes were largely unknown. The demonstration of a direct cross-talk between autophagy and NF-κB opens up new frontiers for deciphering the role of autophagy in diverse biological processes. Here, we review our current understanding of autophagy, with a focus on its role in tumor suppression, NF-κB inactivation and selective protein degradation in mammals. We also list some most intriguing and outstanding questions that are likely to engage researchers in the near future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 3–4, June–August 2007, Pages 233–243
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 3–4, June–August 2007, Pages 233–243
نویسندگان
Gutian Xiao,