کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170820 1549506 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagy and NF-κB: Fight for fate
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Autophagy and NF-κB: Fight for fate
چکیده انگلیسی

Autophagy/macroautophagy is known for its role in cellular homeostasis, development, cell survival, aging, immunity, cancer and neurodegeneration. However, until recently, the mechanisms by which autophagy contributes to these important processes were largely unknown. The demonstration of a direct cross-talk between autophagy and NF-κB opens up new frontiers for deciphering the role of autophagy in diverse biological processes. Here, we review our current understanding of autophagy, with a focus on its role in tumor suppression, NF-κB inactivation and selective protein degradation in mammals. We also list some most intriguing and outstanding questions that are likely to engage researchers in the near future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 3–4, June–August 2007, Pages 233–243
نویسندگان
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