کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170844 1549507 2007 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
چکیده انگلیسی

Pathophysiology of Chagas’ disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production, nitric oxide synthesis, and consequent control of parasitemia and mortality. Cell-mediated immunity in Trypanosoma cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell-mediated immunity of infected subjects. Finally, leukocyte influx towards target tissues is regulated by cytokines, chemokines, and extracellular matrix components which may represent potential therapeutic targets in infected patients. Here we will discuss recent findings on the role of cytokines, chemokines and extracellular matrix components in the regulation of innate and adaptive immunity during T. cruzi infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 1–2, February–April 2007, Pages 107–124
نویسندگان
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