Platelet-rich plasma and chronic wounds: remaining fibronectin may influence matrix remodeling and regeneration success

BackgroundPlatelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules.AimWe hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich plasma preparations.MethodsRecent reports were analyzed and presented as direct evidences of this hypotheses.ResultsFibronectin may directly influence the extracellular matrix remodeling during wound repair. This effect is probably through matrix metalloproteinase expression, thus exerting an extra effect on chronic wound regeneration.ConclusionsPhysicians should be well aware of the possible fibronectin-induced effects in their future endeavors with PRP in chronic wound treatment.