کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2172139 | 1093524 | 2009 | 8 صفحه PDF | دانلود رایگان |
Background aimsImmune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by an accelerated destruction of platelets as a result of the presence of autoreactive antibodies. Patients with ITP also display activated platelet-autoreactive T cells. Mesenchymal stem cells (MSC) inhibit both T- and B-cell activation and may have functional impairments in autoimmune disorders.MethodsWe analyzed the potential role of MSC in the pathogenesis of ITP.ResultsMSC from ITP showed an impaired proliferative capacity and a lower capability of inhibiting activated T-cell proliferation compared with healthy donors. While MSC from controls showed a decreased expression of p27 after stimulation with platelet-derived growth factor, this effect was not observed in MSC from patients. Furthermore, MSC from healthy donors down-regulated p16 upon exposure to platelet-released supernatant, while this effect was not observed for ITP. Interestingly, caspase 9 expression was higher in MSC from ITP.ConclusionsThese abnormalities suggest a role of MSC malfunction in the physiopathology of the disease and may have therapeutic implications.
Journal: Cytotherapy - Volume 11, Issue 6, 2009, Pages 698–705