کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2173847 1093758 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell autonomous specification of temporal identity by Caenorhabditis elegans microRNA lin-4
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Cell autonomous specification of temporal identity by Caenorhabditis elegans microRNA lin-4
چکیده انگلیسی

MicroRNAs provide developing systems with substantial flexibility in posttranscriptional gene regulation. Despite advances made in understanding microRNA structure and function, the relationships between their site-of-synthesis and site-of-action (“autonomy” versus “non-autonomy”) remain an open question. Given the well-defined role of microRNA lin-4 in a reproducible series of time-specific developmental switches, lin-4 is an excellent candidate for understanding whether microRNAs and the resulting heterochronic regulatory pathway have the potential to act cell autonomously. By monitoring temporal development and reporter activity in animals where lin-4 is modulated, we have demonstrated that lin-4 acts cell autonomously to specify temporal identity. This work (i) provides an example of cell autonomy in microRNA functions, and (ii) reveals a cell autonomous component of temporal regulation in C. elegans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 344, Issue 2, 15 August 2010, Pages 603–610
نویسندگان
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