کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2175610 1093846 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Notch signaling pathway in the cnidarian Hydra
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The Notch signaling pathway in the cnidarian Hydra
چکیده انگلیسی
Many of the major pathways that govern early development in higher animals have been identified in cnidarians, including the Wnt, TGFβ and tyrosine kinase signaling pathways. We show here that Notch signaling is also conserved in these early metazoans. We describe the Hydra Notch receptor (HvNotch) and provide evidence for the conservation of the Notch signaling mode via regulated intramembrane proteolysis. We observed that nuclear translocation of the Notch intracellular domain (NID) was inhibited by the synthetic γ-secretase inhibitor DAPT. Moreover, DAPT treatment of hydra polyps caused distinct differentiation defects in their interstitial stem cell lineage. Nerve cell differentiation proceeded normally but post-mitotic nematocyte differentiation was dramatically reduced. Early female germ cell differentiation was inhibited before exit from mitosis. From these results we conclude that γ-secretase activity and presumably Notch signaling are required to control differentiation events in the interstitial cell lineage of Hydra.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 303, Issue 1, 1 March 2007, Pages 376-390
نویسندگان
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