کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2177901 1094692 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bruno Inhibits the Expression of Mitotic Cyclins during the Prophase I Meiotic Arrest of Drosophila Oocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Bruno Inhibits the Expression of Mitotic Cyclins during the Prophase I Meiotic Arrest of Drosophila Oocytes
چکیده انگلیسی

SummaryAnimal oocytes undergo a highly conserved developmental arrest in prophase of meiosis I. The maintenance of the prophase I arrest requires the silencing of Cdk1 activity. Drosophila oocytes inhibit the accumulation of the mitotic cyclins, the activating subunits of Cdk1, via a poorly defined posttranscriptional mechanism. Here, we demonstrate that the translational repressor Bruno binds the 3′ UTR and inhibits the translation of the mitotic cyclin Cyclin A during prophase of meiosis I. In the absence of Bruno, ovarian cysts enter meiosis but rapidly accumulate high levels of mitotic cyclins and return to the mitotic cycle. Based on our results, we propose a model in which Bruno and the anaphase-promoting complex/cyclosome act together to restrict the accumulation of the mitotic cyclins, and thus Cdk1 activity, during the prophase I arrest of the Drosophila oocyte.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 10, Issue 1, January 2006, Pages 127–135
نویسندگان
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