کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2178503 1549699 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spatiotemporal regulation of Src and its substrates at invadosomes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Spatiotemporal regulation of Src and its substrates at invadosomes
چکیده انگلیسی

In the past decade, substantial progress has been made in understanding how Src family kinases regulate the formation and function of invadosomes. Invadosomes are organized actin-rich structures that contain an F-actin core surrounded by an adhesive ring and mediate invasive migration. Src kinases orchestrate, either directly or indirectly, each phase of the invadosome life cycle including invadosome assembly, maturation and matrix degradation and disassembly. Complex arrays of Src effector proteins are involved at different stages of invadosome maturation and their spatiotemporal activity must be tightly regulated to achieve effective invasive migration. In this review, we highlight some recent progress and the challenges of understanding how Src is regulated temporally and spatially to orchestrate the dynamics of invadosomes and mediate cell invasion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cell Biology - Volume 91, Issues 11–12, November–December 2012, Pages 878–888
نویسندگان
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