Keywords: C; catechin; CNS; central nervous system; ConA; concanavalin-A; EC; epicatechin; ECM; extracellular matrix; EGC; epigallocatechin; EGCg; epigallocatechin gallate; GBM; glioblastoma; 67LR; 67â¯kâ¯kDa laminin receptor; LRP-1; low-density-lipoprotein recep
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Keywords: AIF; Apoptosis-inducing factor; cDNA; complementary DNA; DIABLO; Direct IAP binding protein with low pI; EGF; Epidermal growth factor; GMCSF; Granulocyte Macrophage colony-stimulating factor; HER-2; Human epidermal growth factor receptor 2; IAP; Inhibitor
Keywords: ACEi; angiotensin-converting-enzyme inhibitor; ADAMTS2; A disintegrin and metalloproteinase with thrombospondin motifs 2; BiVAD; biventricular assist device; DCM; dilated cardiomyopathy; ECM; extracellular matrix; EDTA; ethylenediaminetetraacetic acid; HF
Keywords: BMP; bone morphogenetic protein; DEXA; dual energy X-ray absorptiometry; DMP; dentin matrix protein; ECM; extracellular matrix; FGF; fibroblast growth factor; HSC; hematopoietic stem cell; MAGP; microfibril associated glycoproteins; MEPE; matrix extracell
Keywords: ADAM; A Disintegrin And Metalloprotease Domain; AHR; airway hyperreponsiveness; Ang; angiopoietin; ASM; airway smooth muscle; BALf; bronchoalveolar lavage fluid; bFGF; basic fibroblast growth factor; BM; basement membrane; Col; collagen; CTGF; connective
Keywords: ECM; extracellular matrix; BCC; breast cancer cell; CM; conditioned media; TEM; trans-endothelial migration; GAG; glycosaminoglycan; HS; heparan sulfate; CS; chondroitin sulfate; HA; hyaluronan; UPS; ubiquitin proteasome system; FBS; fetal bovine serum; H
Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Keywords: Abl; ableson kinase; ABR; actin binding repeat; Arg; ableson related gene kinase; Arp2/3; actin related protein 2/3; ATAT1; alpha-tubulin N-acetyltransferase 1; DMEM; Dulbecco's modified Eagle's medium; DOX; doxycycline; Erk; extracellular signal-re
Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury
Keywords: α-SMA; α-smooth muscle actin; BSA; bovine serum albumin; CKD; chronic kidney disease; CQ; chloroquine; DLS; dynamic light scattering; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; GF; growth factor; MCP; monocyte chemoattractant pro
The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery
Keywords: ADAMs; a disintegrin and metalloproteinases; ADAMTS; ADAMs with thrombospondin motifs; BALF; bronchoalveolar lavage fluid; BAPN; β-aminopropionitrile; CD; Crohn's disease; ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; EndoMT; endo
Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov
Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure
Keywords: COS; chitosan oligosaccharides; GnT-V; N-acetylglucosaminyltransferase V; DSA; datura stramonium; L4-PHA; leuko-agglutinating phytohemagglutinin; GlcNAc; N-acetylglucosamine; GalT; galactosyltransferase; GlcNAcT; N-acetylglucosaminyltransferase; DP; degre
Dual signaling evoked by oxidized LDLs in vascular cells
Keywords: AAPH; 2,2'-azobis(2-amidinopropane) dihydrochloride; AIF; apoptotic inducing factor; AMVN; 2,4-dimethylvaleronitrile; AP-1; activator protein 1; ATF6; activating transcription factor 6; CDE; clathrin-dependent endocytosis; CCL2; chemokine ligand 2 (or MCP
The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination
Keywords: Melanoma; Growth; Invasion; Migration; Metastasis; MT1-MMP; MMP2; ND-322;
Research paperTGF-β1 promotes linear invadosome formation in hepatocellular carcinoma cells, through DDR1 up-regulation and collagen I cross-linking
Keywords: TGF-β1; transforming growth factor beta1; LOX; lysyl oxidase; LOXL2; lysyl oxidase-like2; MMP-2; matrix metalloproteinase-2; MT1-MMP; membrane type-1 matrix metalloproteinase 1; DDR1; discoidin domain receptor 1; HCC; hepatocellular carcinoma; ECM; extra
Simvastatin inhibits CD44 fragmentation in chondrocytes
Keywords: Chondrocyte; Pericellular matrix; Statin; CD44; Lipid raft; ADAM10; HA; hyaluronan; OA; osteoarthritis; OSM; Oncostatin M; BAC; bovine articular chondrocytes; HAC; human articular chondrocytes; MT1-MMP; membrane type I metalloproteinase; ICD; intracellula
Role of β-catenin signaling in the anti-invasive effect of the omega-3 fatty acid DHA in human melanoma cells
Keywords: DHA; docosahexaenoic acid; MITF; microphtalmia transcription factor; PKA; protein kinase A; MMP; metalloproteinase; MT1-MMP; membrane type 1 metalloproteinase; LC-PUFA; long chain polyunsaturated fatty acids; β-Catenin; Docosahexaenoic acid; Invasion; Me
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells
Keywords: Dynamin; Invadopodia; Bladder cancer; Cortactin; Actin; Arp2/3; actin related protein 2 and 3; WASP; Wiskott-Aldrich Syndrome protein; WIP; WASP-interacting protein; MMP2/9; matrix metalloprotease 2 and 9; MT1-MMP; membrane type-I matrix metalloprotease;
The store-operated Ca2Â + entry-mediated signaling is important for cancer spread
Keywords: bFGF; basic fibroblast growth factor; CRAC; calcium release-activated channels; CAD; CRAC activation domain;; CaM kinase II; Ca2Â +/calmodulin-dependent protein kinase II; ER; endoplasmic reticulum; EGF; epidermal growth factor; ECM; extracellular matrix;
Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy
Keywords: Ab; antibody; ACL; anterior cruciate ligament; ADAMTS-4; a disintegrin and metalloproteinase with thrombospondin motifs 4; ADAMTS-5; a disintegrin and metalloproteinase with thrombospondin motifs 5; AGE; advanced glycation end product; AIA; antigen induce
Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP
Keywords: Angiogenesis; Mechanotransduction; Sprouting; Furin; ECs; endothelial cells; MT1-MMP; membrane type-1 matrix metalloproteinase; ECM; extracellular matrix; WSS; wall shear stress; S1P; sphingosine 1-phosphate; PC; proprotein convertase; 3D; three-dimension
Development of PEGylated peptide probes conjugated with 18F-labeled BODIPY for PET/optical imaging of MT1-MMP activity
Keywords: MT1-MMP; Positron emission tomography (PET); Optical imaging; Polyethylene glycol (PEG); Peptide;
Moesin regulates the motility of oral cancer cells via MT1-MMP and E-cadherin/p120-catenin adhesion complex
Keywords: Moesin; E-cadherin/p120-catenin; MT1-MMP; Oral squamous cell carcinoma; Cell motility;
Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway
Keywords: DMEM; Dulbecco's modified Eagle's medium; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; FAK; focal adhesion kinase; MT1-MMP; membrane-type 1 matrix metalloproteinase; PBS; phosphate-buffered saline; PTEN; phosphatase and tensi
Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasion
Keywords: MMP; matrix metalloproteinase; ECM; extracellular matrix; CAT; catalytic domain; MT-MMP; membrane-tethered MMP; S-MMP; soluble MMP; MT1-MMP; Contractility; Force; Pancreatic cancer; Function-blocking antibody; Cleavage peptide;
Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP)
Keywords: BRCA2; MT1-MMP; Centrosome;
Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
Keywords: ER; estrogen receptor; PgR; progesterone receptor; HER2/erbB2; human epidermal growth factor receptor-2; E2; estradiol; RTK; receptor tyrosine kinase; IGF-IR; insulin-like growth factor I receptor; EGFR; epidermal growth factor receptor; MAPK; mitogen act
Cholesterol depletion induces ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell
Keywords: Cholesterol; ANTXR2; ERK phosphorylation; MT1-MMP; MMP-2;
The extracellular domain of syndecan-2 regulates the interaction of HCT116 human colon carcinoma cells with fibronectin
Keywords: ECM; extracellular matrix; FGF2; fibroblast growth factor 2; FN; fibronectin; MMP; matrix metalloproteinase; mPADs; microfabricated post array detector system; MT1-MMP; membrane-type-1 matrix metalloprotease; PDMS; polydimethyl siloxane; Syndecan-2; Colon
Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells
Keywords: ConA; Concanavalin-A; CSF; colony stimulating factor; ECM; extracellular matrix; JAK; janus kinase; MSC; mesenchymal stromal cells; MT1-MMP; membrane type-1 matrix metalloproteinase; STAT; signal transducers and activators of transcription; TLRs; Toll-lik
MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells
Keywords: MT1-MMP; MMP-2; HUVECs; Angiogenesis;
Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK
Keywords: ADAM; a disintegrin and metalloproteinase domain; AP-1; activator protein-1; ARB; angiotensin receptor blockers; AT1; angiotensin II type 1 receptor; AT2; angiotensin II type II receptor; CF; cardiac fibroblasts; CMV; cytomegalovirus; CVD; cardiovascular
Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition
Keywords: 2-DG; 2-deoxy-D-glucose; 2-DG6P; 2-deoxy-d-glucose-6-phosphate; AHR; aryl hydrocarbon receptor; Arg1; arginase 1; ARNT; AHR nuclear translocator; bFGF; basic fibroblast growth factor; CAF; cancer associated fibroblast; CCL5; C-C chemokine ligand 5; CSF-1;
N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells
Keywords: ECM, extracellular matrix; GlcNAc, N-acetylglucosamine; GnT-V, N-acetylglucosaminyltransferase V; MT1-MMP, membrane-type 1 matrix metalloproteinase; TIMP-1, tissue inhibitor of metalloproteinase-1GnT-V; MMP-2; MT1-MMP; Tumor progression
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression
Keywords: Microglia; Glioma; Atorvastatin; MT1-MMP; Migration; Invasion
PDGF-BB-induced MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling
Keywords: PDGF-BB; MT1-MMP; Invasion; Proliferation; 3-Dimensional collagen; Basement membrane
Podosomes are dispensable for osteoclast differentiation and migration
Keywords: Osteoclast; Podosome; Actin; Cofilin; Integrin; Adhesion; Manganese; Myeloid; MMP14; MT1-MMP
The tetraspanin network modulates MT1-MMP cell surface trafficking
Keywords: Cancer; Tetraspanin; MT1-MMP; Cell surface trafficking; Protein-protein interaction;
MT1-MMP modulates the mechanosensitivity of osteocytes
Keywords: MT1-MMP; Mechanosensitivity; Osteocytes; Pulsating fluid flow; Mechanical loading;
Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?
Keywords: Cryptorchidism; Gonocyte transformation; Matrix metalloproteinase; MT1-MMP; TIMP2; Infertility;
Site-specific cellular functions of MT1-MMP
Keywords: MT1-MMP; Subcellular location; Cell migration; Cell metabolism; Hypoxia; Chromatin remodeling; Macrophages; Inflammation; Endothelial cells; Angiogenesis
Mechanisms of human smooth muscle cell proliferation and transplant vasculopathy induced by HLA class I antibodies: In vitro and in vivo studies
Keywords: TV; transplant vasculopathy; HLA; human leukocyte antigen; SMC; smooth muscle cells; EC; endothelial cells; MMP; matrix metalloproteinases; MMP-2; matrix metalloproteinase 2; FAK; focal adhesion kinase; mTOR; mammalian target of rapamycin; PI3K; phosphati
Role of MT1-MMP in Estrogen-Mediated Cellular Processes of Intimal Hyperplasia
Keywords: matrix metalloproteinase; MT1-MMP; gene silencing; estrogen; intimal hyperplasia
Spatiotemporal regulation of Src and its substrates at invadosomes
Keywords: Src; Invasion; Invadosome; Invadopodia; Podosome; Rosette; Rho; Cdc42; FAK; Cortactin; Mabp1; ROS; MT1-MMP
Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma
Keywords: CAFs; carcinoma-associated fibroblasts; COX-2; prostaglandin-endoperoxide synthase 2; DEX; dexamethasone; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition; FBS; foetal bovine serum; FN; fibronectin; HNSCC; head and neck squamous cell c
Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy
Keywords: CTGF; connective tissue growth factor; DMEM; Dulbecco's modified Eagle's media; DN; diabetic nephropathy; ECM; extracellular matrix; FBS; fetal bovine serum; HG; high glucose; HRMC; human renal mesangial cells; ICAM-1; intracellular cell adhesion molecule
The role of pseudokinases in cancer
Keywords: ALL; Acute Lymphoblastic Leukaemia; AML; Acute Myeloid Leukaemia; AMPK; 5â²-Adenosine Monophosphate Activated Protein Kinase; ATF4; Activating Transcriptional Factor 4; ATP; Adenosine-5â²-Triphosphate; BTICs; Brain Tumour-Initiating Cells; C/EBPα; CCAA
Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent?
Keywords: Testicular descent; Cryptorchidism; Gubernaculum; Inguinal fat pad; Matrix metalloproteinase; MT1-MMP
Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion
Keywords: MT1-MMP; Membrane-type-1 matrix metalloproteinase; APBA3; amyloid beta (A4) precursor protein-binding, family A, member 3; HIF-1; Hypoxia Inducible Factor-1; FIH-1; Factor of Inhibiting HIF-1; ECM; extracellular matrix; ATP; adenosine triphosphate; MEF; m
Concanavalin A: A potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics
Keywords: BHA; butylated hydroxyanisole; BNIP3; adenovirus E1B 19Â kDa-interacting protein 3; ConA; Concanavalin A; COX-2; cyclooxygenase-2; Cyto c; cytochrome c; DAPK; dual-specificity protein kinase; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activ
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression
Keywords: Minocycline; Microglia; Glioma; MT1-MMP;