The extracellular domain of syndecan-2 regulates the interaction of HCT116 human colon carcinoma cells with fibronectin

► Syndecan-2 overexpression enhanced the spreading of HCT116 cells on fibronectin. ► Syndecan-2 extracellular domain is involved in cell-substratum adhesion. ► Syndecan-2 enhanced the interaction affinity of HCT116 cells on fibronectin. ► Syndecan-2 oligomerization enhanced adhesion-related functions.