کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10435858 911017 2016 51 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy
چکیده انگلیسی
Cartilage damage is a hallmark of osteoarthritis for which no medical therapy is currently available. The delivery of pharmacologic agents into specific cartilage sub-compartments after both systemic and intra-articular administration is inefficient, thus limiting the ability to reestablish cartilage homeostasis. This problem has been recently tackled through to the use of cartilage-targeted nanodrugs. This review describes the nanodrugs that have been targeted to specific cartilage components or chondrocytes receptors to block the action of key molecular mediators within the cartilage or manipulate pathways related to osteoarthritis development in chondrocytes, respectively.94
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 12, Issue 2, February 2016, Pages 255-268
نویسندگان
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