Candida albicans HSP12 is co-regulated by physiological CO2 and pH

Global transcriptional analysis of Candida albicans exposed to elevated ambient CO2 revealed a statistically significant differential regulation of 14 genes. Subsequent RNA hybridisation analysis of one gene, HSP12, confirmed CO2-regulation via a cAMP-dependent mechanism. Additionally, Northern analyses and gel mobility shift assays demonstrate the co-regulation of HSP12 by environmental pH via a Rim101-dependent mechanism.