کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182344 1095458 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling
چکیده انگلیسی

Mutations in the gene encoding the zinc finger transcription factor TRPS1 result in tricho-rhino-phalangeal syndrome, characterized by craniofacial and skeletal abnormalities, and sparse scalp hair. In this study, Trps1 was identified by microarray hybridization analysis as having a complex pattern of spatiotemporal regulation in murine skin during morphogenesis. During early skin development, Trps1 expression decreased in the epidermis while simultaneously increasing in the dermis. Trps1 was specifically expressed in the nuclei of mesenchymal cells during hair follicle morphogenesis. An analysis of Trps1 expression during postnatal murine hair follicle cycling revealed that the protein localized to the nuclei of dermal papillae cells during telogen and anagen. Additionally, we found that Trps1 consistently localized to the nuclei of dermal papillae cells and the highly proliferative epithelial cells of mouse, rat and human hair follicles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 8, Issue 2, January 2008, Pages 51–57
نویسندگان
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