کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182594 1402088 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reprogramming towards endothelial cells for vascular regeneration
ترجمه فارسی عنوان
برنامه ریزی مجدد سلول های اندوتلیال برای احیای عروق
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genes & Diseases - Volume 3, Issue 3, September 2016, Pages 186–197
نویسندگان
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