کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182650 1095500 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unraveling the molecular genetics of head and neck cancer through genome-wide approaches
ترجمه فارسی عنوان
تجزیه و تحلیل ژنتیک مولکولی سرطان سر و گردن از طریق رویکردهای گسترده ژنوم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas (HNSCC). Genome-wide sequencing projects have identified a number of recurrently mutated genes, including unexpected alterations in the NOTCH pathway and chromatin related genes. Gene-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma biology. The identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic strategies. The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genes & Diseases - Volume 1, Issue 1, September 2014, Pages 75–86
نویسندگان
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