کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2184516 1095875 2013 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IFITMs Restrict the Replication of Multiple Pathogenic Viruses
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
IFITMs Restrict the Replication of Multiple Pathogenic Viruses
چکیده انگلیسی


• IFITMs are host intramembrane proteins that block viral fusion resulting in virus degradation.
• IFITMs inhibit a growing number of pathogenic viruses, including influenza A virus, dengue virus, and Ebola virus.
• Mice null for Ifitm3 exhibit increased disease severity when infected with the influenza A virus.
• Patients expressing a variant allele of IFITM3 are more likely to develop severe influenza infection.
• Recent work suggests that IFITMs may toughen the host membrane, thus preventing viral membrane fusion.

The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 425, Issue 24, 13 December 2013, Pages 4937–4955
نویسندگان
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