کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2184521 1095875 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of MAVS Regulation at the Mitochondrial Membrane
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Mechanisms of MAVS Regulation at the Mitochondrial Membrane
چکیده انگلیسی


• We review the basic pathways of innate immune signaling that converge on MAVS.
• We review the MAVS “regulome”.
• We review mechanisms by which these regulators alter MAVS signaling.

Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This is due in large part to the mitochondrial localization of the innate immune signaling adaptor MAVS (mitochondrial antiviral signaling protein), which coordinates signals received from two independent cytosolic pathogen recognition receptors (PRRs) to induce antiviral genes. The existence of a shared adaptor for two central PRRs presents an ideal target by which the host cell can prevent cellular damage induced by uncontrolled inflammation through alteration of MAVS expression and/or signaling. In this review, we focus on the MAVS regulome and review the cellular factors that regulate MAVS by (1) protein–protein interactions, (2) alterations in mitochondrial dynamics, and/or (3) post-translational modifications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 425, Issue 24, 13 December 2013, Pages 5009–5019
نویسندگان
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