کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2188288 1096161 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-Edge Interactions in a Pentadecameric Human Antibody Vκ Domain
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
β-Edge Interactions in a Pentadecameric Human Antibody Vκ Domain
چکیده انگلیسی

Antibodies are the archetypal molecules of the Ig-fold superfamily. Their highly conserved β-sheet architecture has evolved to avoid aggregation by protecting edge strands. However, the crystal structure of a human Vκ domain described here, reveals an exposed β-edge strand which mediates assembly of a helical pentadecameric oligomer. This edge strand is highly conserved in Vκ domains but is both shortened and capped by the use of two sequential trans-proline residues in Vλ domains. We suggest that the exposure of this β-edge in Vκ domains may explain why light-chain deposition disease is mediated predominantly by κ antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 367, Issue 3, 30 March 2007, Pages 603–608
نویسندگان
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