کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2189371 1096209 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reducing Intrinsic Biochemical Noise in Cells and Its Thermodynamic Limit
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Reducing Intrinsic Biochemical Noise in Cells and Its Thermodynamic Limit
چکیده انگلیسی

In living cells, the specificity of biomolecular recognition can be amplified and the noise from non-specific interactions can be reduced at the expense of cellular free energy. This is the seminal idea in the Hopfield-Ninio theory of kinetic proofreading: The specificity is increased via cyclic network kinetics without altering molecular structures and equilibrium affinites. We show a thermodynamic limit of the specificity amplification with a given amount of available free energy. For a normal cell under physiological condition with sustained phosphorylation potential, this gives a factor of 1010 as the upper bound in specificity amplification. We also study an optimal kinetic network design that is capable of approaching the thermodynamic limit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 362, Issue 3, 22 September 2006, Pages 387–392
نویسندگان
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