کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2189371 | 1096209 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Reducing Intrinsic Biochemical Noise in Cells and Its Thermodynamic Limit Reducing Intrinsic Biochemical Noise in Cells and Its Thermodynamic Limit](/preview/png/2189371.png)
In living cells, the specificity of biomolecular recognition can be amplified and the noise from non-specific interactions can be reduced at the expense of cellular free energy. This is the seminal idea in the Hopfield-Ninio theory of kinetic proofreading: The specificity is increased via cyclic network kinetics without altering molecular structures and equilibrium affinites. We show a thermodynamic limit of the specificity amplification with a given amount of available free energy. For a normal cell under physiological condition with sustained phosphorylation potential, this gives a factor of 1010 as the upper bound in specificity amplification. We also study an optimal kinetic network design that is capable of approaching the thermodynamic limit.
Journal: Journal of Molecular Biology - Volume 362, Issue 3, 22 September 2006, Pages 387–392