Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation

► CD-NP is a chimeric natriuretic peptide made of CNP and the C-terminal tail of DNP. ► CD-NP and DNP were shown to be highly resistant to proteolytic degradation. ► Resistance to degradation may contribute to the therapeutic properties of CD-NP. ► Addition of the C-terminal DNP tail may increase the half-life of natriuretic peptides.