کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2196458 1550923 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitamin D metabolism within bone cells: Effects on bone structure and strength
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Vitamin D metabolism within bone cells: Effects on bone structure and strength
چکیده انگلیسی

The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)2D3) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D3) to 1,25(OH)2D3, which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)2D3 in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 347, Issues 1–2, 5 December 2011, Pages 42–47
نویسندگان
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