کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197479 1550968 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drosophila is an inclusive model for human diseases, growth and development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Drosophila is an inclusive model for human diseases, growth and development
چکیده انگلیسی

Cytogenetic studies over the last century have led to the complete mapping of the Drosophila polytene chromosomes. The resulting data and the analysis of puffing at specific gene sites, manifestations of enhanced transcriptional activity, have led to the use of the fruit fly as the most well-understood animal model for a plethora of cellular mechanisms and genetic defects. In recent years the fly data base has contributed greatly to the use of Drosophila as a remarkable model for the functional genomics of many human genes. Here I review briefly the diversity of “model genes” studied in this dipteran, ranging from mental acuity, sleep and development, to recent studies from our laboratory, and those of our collaborators, on steroid hormone biosynthesis and neurodegeneration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 293, Issues 1–2, 10 October 2008, Pages 25–31
نویسندگان
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