کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2197547 1550966 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stimulation of human omental adipose tissue lipolysis by growth hormone plus dexamethasone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Stimulation of human omental adipose tissue lipolysis by growth hormone plus dexamethasone
چکیده انگلیسی

Growth hormone [GH] administration results in a reduction in adiposity of humans that is attributed to stimulation of lipolysis. We examined the effect of direct addition of human GH, in both the absence and presence of dexamethasone [Dex], as well as that of interferon β on lipolysis by omental adipose tissue explants from obese women incubated for 48 h in primary culture. There was a significant stimulation of lipolysis by GH in the presence of Dex but not by Dex or GH alone. There was also a significant further stimulation by GH in the presence of Dex of hormone-sensitive lipase, perilipin, lipoprotein lipase and β1 adrenergic receptor mRNA. We conclude that the direct lipolytic effect of GH is accompanied by an increase in HSL mRNA in the presence of DEX, but GH also increased the mRNAs for other proteins that could explain all or part of its lipolytic action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 295, Issues 1–2, 25 November 2008, Pages 101–105
نویسندگان
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