کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2198989 | 1099419 | 2008 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system](/preview/png/2198989.png)
A brain-derived neurotrophic factor (BDNF) receptor TrkB involves three spliced variants, namely the tyrosine kinase domain (TK) intact (+) and two TK(−) isoforms T1 and T2, yet their precise roles are largely unknown. Here we extensively map the mRNA expression patterns of BDNF and TrkB variants, further to gain insights in TK(−) specific functions during mouse development. Consequently, we found that TK(+), T1 and T2 were expressed in distinct regions of the mouse nervous system at the embryonic and postnatal stages, implicating separable functions of TK(−) forms. Additionally we uncovered five expressed segments in the intron between T2 and T1 specific exons, and one of these segments was revealed to code novel TK(−) receptors with unique responsiveness in vitro. These results suggest dynamic modes of expression from the Ntrk2 gene locus and multiple roles of TK(−) forms in the developing mouse nervous system.
Journal: Molecular and Cellular Neuroscience - Volume 39, Issue 3, 29 October 2008, Pages 465–477