کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2199263 1099434 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors
چکیده انگلیسی

Optic nerve (ON) oligodendrocyte precursors (OPCs) are generated under the influence of the Sonic hedgehog (Shh) in the preoptic area from where they migrate to colonise the entire nerve. The molecular events that control this migration are still poorly understood. Recent studies suggested that Shh is often used by the same cell population to control different processes, including cell proliferation and migration, raising the possibility that Shh could contribute to these aspects of OPC development. In support of this idea, we show here that Shh induces the proliferation of OPCs derived from embryonic mouse ON explants and acts as a chemoattractant for their migration. In ovo injections of hybridomas secreting Shh-specific blocking antibody decreases the number of OPCs present in chick ONs, particularly in the retinal portion of the nerve. Altogether these data indicate that Shh contributes to OPC proliferation and distribution along the ON, in addition to their specification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 36, Issue 3, November 2007, Pages 355–368
نویسندگان
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