Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells

► Glutamate facilitates Mn-induced apoptosis in neuronally differentiated P19 cells. ► Apoptotic signals ROS, caspase 3 and JNK increase when the two agents are combined. ► The anti-glutamatergic drug, riluzole, inhibits the apoptotic signals and cell death.