کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2200924 | 1099986 | 2011 | 6 صفحه PDF | دانلود رایگان |
Maternal deprivation (MD) is a well-established protocol used to investigate neurobiological changes that are associated with the etiology of and vulnerability to stress-related diseases in animal models. The resulting psychophysiological effects, the timing and duration of these adverse stimuli, and the method by which they exert their effects on the animals remain unclear. This study characterized differences in the hippocampal expression of glucocorticoid receptors (GRs) and the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) in male and female rats that underwent different MD paradigms during the stress hyporesponsive period (SHRP). Both GRs and the two calcium-binding proteins were much more abundant in females than in males. MD paradigms had a significant effect on CALR and CALB expression in both males and females but affected GR levels only in males. Additionally, expression of the two calcium-binding proteins in the hippocampus responded differently to MD-induced stress, especially in females. Taken together, these results indicate that females are able to modulate their response to stress better than males.
► We compare three different maternal deprivation (MD) paradigms in this study.
► We examine changes in the hippocampal expression of three proteins in rats on PND21.
► They were glucocorticoid receptors (GRs), calretinin (CALR) and calbindin-D28k (CALB).
► All the three proteins were much more abundantly expressed in females than in males.
► MD paradigms affected CALR and CALB in both genders but affected GRs only in males.
Journal: Neurochemistry International - Volume 59, Issue 6, November 2011, Pages 847–852