Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons

► Ethanol exerts dual actions on striatal output that are initiated simultaneously. ► Acute ethanol-treatment induces a GABAAR-sensitive short-term depression. ► Ethanol washout induces a long-term facilitation of striatal output. ► Ethanol-induced facilitation is regulated by cholinergic interneurons. ► This study provide important clues for understanding acute ethanol intoxication.