کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2202058 | 1551321 | 2007 | 4 صفحه PDF | دانلود رایگان |
A partial agonist of the N-methyl-d-aspartate (NMDA) receptor, d-cycloserine, acting at its glycine modulatory site, ameliorates the neuropsychiatric symptoms that are mimicked by NMDA antagonists and include cognitive disturbances, antipsychotic-resistant schizophrenic symptoms and cerebellar ataxia. To obtain a further insight into the mechanisms of the therapeutic efficacies of d-cycloserine, we investigated the effects of the systemic administration of d-cycloserine on the extracellular contents of an endogenous NMDA co-agonist, d-serine, in the medial frontal cortex of the rat using an in vivo dialysis technique. An acute intraperitoneal injection of d-cycloserine (50 and 100 mg/kg) caused an increase in extracellular concentrations of d-serine without significant effects on those of l-serine, glycine, l-glutamate, l-aspartate, l-glutamine, l-asparagine, l-alanine, l-threonin and taurine in the medial frontal cortex. The selective increase in the extracellular d-serine contents may, at least partially, be associated with the facilitating effects of d-cycloserine on the NMDA receptor functions in addition to its direct stimulation of the NMDA receptor glycine site.
Journal: Neurochemistry International - Volume 51, Issues 2–4, July–September 2007, Pages 233–236