کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2202681 | 1100380 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The role of Atonal transcription factors in the development of mechanosensitive cells The role of Atonal transcription factors in the development of mechanosensitive cells](/preview/png/2202681.png)
• Atonal transcription factors specify mechanosensitive cells in vertebrates and invertebrates.
• The genetic targets of atonal factors are beginning to be identified.
• Atonal factors promote sensory cell regeneration in some vertebrates, but not mammals.
Mechanosensation is an evolutionarily ancient sensory modality seen in all main animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15–20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups.
Journal: Seminars in Cell & Developmental Biology - Volume 24, Issue 5, May 2013, Pages 438–447