کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202964 1100409 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiology and pathology of proteostasis in the early secretory compartment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Physiology and pathology of proteostasis in the early secretory compartment
چکیده انگلیسی

The endoplasmic reticulum (ER), the port of entry for proteins into the secretory pathway, is a multifunctional organelle emerging as a central integrator of numerous signalling pathways. The mechanisms that control proteostasis are integral part of this signalling network, providing cues for morphological and functional cell remodelling, proliferation, inflammation and cell death. The complexity of ER responses is exploited during physiological and pathological tissue development, cell differentiation and lifespan control. This essay outlines some of the mechanisms that link proteostasis within the early secretory compartment to signalling in development and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 21, Issue 5, July 2010, Pages 520–525
نویسندگان
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