کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2203469 1100458 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of fertilization-initiated [Ca2+]i oscillations in mammalian eggs: A multi-pronged approach
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Regulation of fertilization-initiated [Ca2+]i oscillations in mammalian eggs: A multi-pronged approach
چکیده انگلیسی

The calcium ([Ca2+]i) oscillations associated with mammalian fertilization and required to induce egg activation occur during M-phase stages of the cell cycle. The molecular mechanisms underlying this regulation remain unproven and may be multi-layered. Type 1 inositol 1,4,5-trisphosphate receptors (IP3R-1), which mediate [Ca2+]i release during fertilization, have emerged as key regulatory units because they contain multiple phosphorylation consensus sites and undergo changes in cellular location and mass prior to and following fertilization. Hence, control of IP3R-1 function together with regulation of PLCζ activity, the putative sperm factor, may combine to impart cell cycle and species-specific [Ca2+]i oscillations characteristic of mammalian fertilization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 17, Issue 2, April 2006, Pages 274–284
نویسندگان
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