کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204294 1100766 2016 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
چکیده انگلیسی

The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different biological outcomes including gene activation and cell death induction in the form of apoptosis or necroptosis. RIPK1 is believed to be crucial for regulating the balance between these opposing outcomes. It is therefore not surprising that RIPK1 is highly regulated, most notably by phosphorylation, ubiquitination, and their respective reversals. In this review, we discuss the biological functions of RIPK1 within the context of TNFR1 signaling. Finally, we discuss recent advances in the knowledge on three ubiquitin E3 ligases that exert regulatory functions on RIPK1 signaling: cIAP1, cIAP2, and LUBAC.

TrendsRIPK1 plays a central role in regulating gene activation, apoptosis, and necroptosis.RIPK1 positively and negatively regulates RIPK3- and Caspase-8-mediated cell death.Ubiquitination of RIPK1 by LUBAC and cIAP1/2 prevents RIPK1-mediated death signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 26, Issue 6, June 2016, Pages 445–461
نویسندگان
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