کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204515 1100792 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diversity of cell death pathways: insight from the fly ovary
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Diversity of cell death pathways: insight from the fly ovary
چکیده انگلیسی


• At least five distinct types of cell death occur in the fly ovary.
• Cell death of mid-stage egg chambers uses a novel caspase-dependent pathway that involves autophagy.
• Developmental programmed cell death of ovarian nurse cells occurs independently of canonical cell death pathways.
• These forms of cell death are similar to germline cell death in other organisms.

Multiple types of cell death exist including necrosis, apoptosis, and autophagic cell death. The Drosophila ovary provides a valuable model to study the diversity of cell death modalities, and we review recent progress to elucidate these pathways. At least five distinct types of cell death occur in the ovary, and we focus on two that have been studied extensively. Cell death of mid-stage egg chambers occurs through a novel caspase-dependent pathway that involves autophagy and triggers phagocytosis by surrounding somatic epithelial cells. For every egg, 15 germline nurse cells undergo developmental programmed cell death, which occurs independently of most known cell death genes. These forms of cell death are strikingly similar to cell death observed in the germlines of other organisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 11, November 2013, Pages 567–574
نویسندگان
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