کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204704 1100812 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Histone modifications and mitosis: countermarks, landmarks, and bookmarks
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Histone modifications and mitosis: countermarks, landmarks, and bookmarks
چکیده انگلیسی

The roles of post-translational histone modifications in regulating transcription and DNA damage have been widely studied and discussed. Although mitotic histone marks, particularly phosphorylation, were discovered four decades ago, their roles in mitosis have been outlined only in the past few years. Here we aim to provide an integrated view of how histone modifications act as ‘countermarks’, ‘landmarks’, and ‘bookmarks’ to displace, recruit, and ‘remember’ the location of regulatory proteins during and shortly after mitosis. These capabilities allow histone marks to help downregulate interphase functions such as transcription during mitosis, to facilitate chromatin events required to accomplish chromosome segregation, and to contribute to the maintenance of epigenetic states through mitosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 4, April 2013, Pages 175–184
نویسندگان
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