کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
229912 465056 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A study of adsorptive stripping voltammetric behavior of ofloxacine antibiotic in the presence of Fe(III) and its determination in tablets and biological fluids
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
A study of adsorptive stripping voltammetric behavior of ofloxacine antibiotic in the presence of Fe(III) and its determination in tablets and biological fluids
چکیده انگلیسی

Square-wave voltammetry was used to explore the adsorption property of ofloxacine complex with iron ion on the hanging mercury drop electrode (HMDE). By employing the adsorptive stripping voltammetric approach, a sensitive electroanalytical method for the quantitative analysis of ofloxacine antibiotic was achieved. A well-developed voltammetric peak was obtained in pH 7.5 Britton–Robinson buffer (B–R buffer) at −1400 mV. The cyclic voltammetric studies indicated that the reduction process was irreversible and primarily controlled by adsorption. An investigations of the variation of adsorptive voltammetric peak current with supporting electrolyte, pH, accumulation time, accumulation potential, ion concentration, scan rate, pulse amplitude, SW frequency, working electrode area and convection rate has resulted in the recognition of optimal experimental conditions for ofloxacine analysis. The studied electroanalytical signal showed a linear response for ofloxacine in the concentration range 5 × 10−7 to 1.7 × 10−6 mol l−1 (r = 0.999). A limit of detection of 1.1 × 10−8 mol l−1 (3.98 ppb) with relative standard deviation of 1.21 RSD% and mean recovery of 99.6% were obtained. Possible interferences by several substances usually present in pharmaceutical formulation were also evaluated. The analytical quantification of ofloxacine in commercially available pharmaceutical formulation was performed and compared with data from HPLC technique.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 13, Issue 3, October 2009, Pages 235–241
نویسندگان
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